The Gly2019Ser mutation in LRRK2 is not fully penetrant in familial Parkinson's disease: the GenePD study
Identifieur interne : 002138 ( Main/Exploration ); précédent : 002137; suivant : 002139The Gly2019Ser mutation in LRRK2 is not fully penetrant in familial Parkinson's disease: the GenePD study
Auteurs : Jeanne C. Latourelle [États-Unis] ; Mei Sun [États-Unis] ; Mark F. Lew [États-Unis] ; Oksana Suchowersky [Canada] ; Christine Klein [Allemagne] ; Lawrence I. Golbe [États-Unis] ; Margery H. Mark [États-Unis] ; John H. Growdon [États-Unis] ; G Frederick Wooten [États-Unis] ; Ray L. Watts [États-Unis] ; Mark Guttman [Canada] ; Brad A. Racette [États-Unis] ; Joel S. Perlmutter [États-Unis] ; Anwar Ahmed [États-Unis] ; Holly A. Shill [États-Unis] ; Carlos Singer [États-Unis] ; Stefano Goldwurm [Italie] ; Gianni Pezzoli [Italie] ; Michela Zini [Italie] ; Marie H. Saint-Hilaire [États-Unis] ; Audrey E. Hendricks [États-Unis] ; Sally Williamson [États-Unis] ; Michael W. Nagle [États-Unis] ; Jemma B. Wilk [États-Unis] ; Tiffany Massood [États-Unis] ; Karen W. Huskey [États-Unis] ; Jason M. Laramie [États-Unis] ; Anita L. Destefano [États-Unis] ; Kenneth B. Baker [États-Unis] ; Ilia Itin [États-Unis] ; Irene Litvan [États-Unis] ; Garth Nicholson [Australie] ; Alastair Corbett [Australie] ; Martha Nance [États-Unis] ; Edward Drasby [États-Unis] ; Stuart Isaacson [États-Unis] ; David J. Burn [Royaume-Uni] ; Patrick F. Chinnery [Royaume-Uni] ; Peter P. Pramstaller [Italie] ; Jomana Al-Hinti [États-Unis] ; Anette T. Moller [Danemark] ; Karen Ostergaard [Danemark] ; Scott J. Sherman [États-Unis] ; Richard Roxburgh [Nouvelle-Zélande] ; Barry Snow [Nouvelle-Zélande] ; John T. Slevin [États-Unis] ; Franca Cambi [États-Unis] ; James F. Gusella [États-Unis] ; Richard H. Myers [États-Unis]Source :
- BMC Medicine [ 1741-7015 ] ; 2008.
Abstract
We report age-dependent penetrance estimates for leucine-rich repeat kinase 2 (
A sample, including 903 affected and 58 unaffected members from 509 families ascertained for having two or more PD-affected members, 126 randomly ascertained PD patients and 197 controls, was screened for five different
Thirty-one out of 509 families with multiple cases of PD (6.1%) were found to have 58
Lifetime penetrance of
Url:
DOI: 10.1186/1741-7015-6-32
PubMed: 18986508
PubMed Central: 2596771
Affiliations:
- Allemagne, Australie, Canada, Danemark, Italie, Nouvelle-Zélande, Royaume-Uni, États-Unis
- Alberta, Californie, Missouri (État), Ontario
- Calgary, Los Angeles, Saint-Louis (Missouri), Sydney, Toronto
- Université de Calgary, Université de Californie du Sud, Université de Toronto, École de médecine (Université Washington de Saint-Louis)
Links toward previous steps (curation, corpus...)
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- to stream Ncbi, to step Merge: 000978
- to stream Ncbi, to step Curation: 000978
- to stream Ncbi, to step Checkpoint: 000978
- to stream Main, to step Merge: 002321
- to stream Main, to step Curation: 002138
Le document en format XML
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is not fully penetrant in familial Parkinson's disease: the GenePD study</title>
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<author><name sortKey="Hendricks, Audrey E" sort="Hendricks, Audrey E" uniqKey="Hendricks A" first="Audrey E" last="Hendricks">Audrey E. Hendricks</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:aff id="I1">Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA</wicri:regionArea>
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<author><name sortKey="Huskey, Karen W" sort="Huskey, Karen W" uniqKey="Huskey K" first="Karen W" last="Huskey">Karen W. Huskey</name>
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<wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:aff id="I16">Department of Biostatistics, Boston University School of Medicine, Boston University, Boston, MA, USA</nlm:aff>
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<author><name sortKey="Corbett, Alastair" sort="Corbett, Alastair" uniqKey="Corbett A" first="Alastair" last="Corbett">Alastair Corbett</name>
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<author><name sortKey="Nance, Martha" sort="Nance, Martha" uniqKey="Nance M" first="Martha" last="Nance">Martha Nance</name>
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<author><name sortKey="Drasby, Edward" sort="Drasby, Edward" uniqKey="Drasby E" first="Edward" last="Drasby">Edward Drasby</name>
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<author><name sortKey="Isaacson, Stuart" sort="Isaacson, Stuart" uniqKey="Isaacson S" first="Stuart" last="Isaacson">Stuart Isaacson</name>
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<author><name sortKey="Burn, David J" sort="Burn, David J" uniqKey="Burn D" first="David J" last="Burn">David J. Burn</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne</wicri:regionArea>
<wicri:noRegion>Newcastle upon Tyne</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chinnery, Patrick F" sort="Chinnery, Patrick F" uniqKey="Chinnery P" first="Patrick F" last="Chinnery">Patrick F. Chinnery</name>
<affiliation wicri:level="1"><nlm:aff id="I24">Regional Neurosciences Centre, Newcastle University, Newcastle upon Tyne, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Regional Neurosciences Centre, Newcastle University, Newcastle upon Tyne</wicri:regionArea>
<wicri:noRegion>Newcastle upon Tyne</wicri:noRegion>
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</author>
<author><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P" last="Pramstaller">Peter P. Pramstaller</name>
<affiliation wicri:level="1"><nlm:aff id="I25">Department of Neurology, General Regional Hospital Bolzano, Bolzano, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Neurology, General Regional Hospital Bolzano, Bolzano</wicri:regionArea>
<wicri:noRegion>Bolzano</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Al Hinti, Jomana" sort="Al Hinti, Jomana" uniqKey="Al Hinti J" first="Jomana" last="Al-Hinti">Jomana Al-Hinti</name>
<affiliation wicri:level="1"><nlm:aff id="I26">Department of Neurology, University of Arkansas for Medical Sciences, AR, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of Arkansas for Medical Sciences, AR</wicri:regionArea>
<wicri:noRegion>AR</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Moller, Anette T" sort="Moller, Anette T" uniqKey="Moller A" first="Anette T" last="Moller">Anette T. Moller</name>
<affiliation wicri:level="1"><nlm:aff id="I27">Department of Neurology, Aarhus University Hospital, Aarhus, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Neurology, Aarhus University Hospital, Aarhus</wicri:regionArea>
<wicri:noRegion>Aarhus</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ostergaard, Karen" sort="Ostergaard, Karen" uniqKey="Ostergaard K" first="Karen" last="Ostergaard">Karen Ostergaard</name>
<affiliation wicri:level="1"><nlm:aff id="I27">Department of Neurology, Aarhus University Hospital, Aarhus, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Neurology, Aarhus University Hospital, Aarhus</wicri:regionArea>
<wicri:noRegion>Aarhus</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sherman, Scott J" sort="Sherman, Scott J" uniqKey="Sherman S" first="Scott J" last="Sherman">Scott J. Sherman</name>
<affiliation wicri:level="1"><nlm:aff id="I28">Department of Neurology, University of Arizona, Tucson, AZ, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of Arizona, Tucson, AZ</wicri:regionArea>
<wicri:noRegion>AZ</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Roxburgh, Richard" sort="Roxburgh, Richard" uniqKey="Roxburgh R" first="Richard" last="Roxburgh">Richard Roxburgh</name>
<affiliation wicri:level="1"><nlm:aff id="I29">Department of Neurology, Auckland City Hospital, Auckland, New Zealand</nlm:aff>
<country xml:lang="fr">Nouvelle-Zélande</country>
<wicri:regionArea>Department of Neurology, Auckland City Hospital, Auckland</wicri:regionArea>
<wicri:noRegion>Auckland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Snow, Barry" sort="Snow, Barry" uniqKey="Snow B" first="Barry" last="Snow">Barry Snow</name>
<affiliation wicri:level="1"><nlm:aff id="I29">Department of Neurology, Auckland City Hospital, Auckland, New Zealand</nlm:aff>
<country xml:lang="fr">Nouvelle-Zélande</country>
<wicri:regionArea>Department of Neurology, Auckland City Hospital, Auckland</wicri:regionArea>
<wicri:noRegion>Auckland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Slevin, John T" sort="Slevin, John T" uniqKey="Slevin J" first="John T" last="Slevin">John T. Slevin</name>
<affiliation wicri:level="1"><nlm:aff id="I30">Department of Neurology, University of Kentucky College of Medicine, Lexington, KY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of Kentucky College of Medicine, Lexington, KY</wicri:regionArea>
<wicri:noRegion>KY</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cambi, Franca" sort="Cambi, Franca" uniqKey="Cambi F" first="Franca" last="Cambi">Franca Cambi</name>
<affiliation wicri:level="1"><nlm:aff id="I30">Department of Neurology, University of Kentucky College of Medicine, Lexington, KY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of Kentucky College of Medicine, Lexington, KY</wicri:regionArea>
<wicri:noRegion>KY</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gusella, James F" sort="Gusella, James F" uniqKey="Gusella J" first="James F" last="Gusella">James F. Gusella</name>
<affiliation wicri:level="1"><nlm:aff id="I2">Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School Boston, MA</wicri:regionArea>
<wicri:noRegion>MA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Myers, Richard H" sort="Myers, Richard H" uniqKey="Myers R" first="Richard H" last="Myers">Richard H. Myers</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA</wicri:regionArea>
<wicri:noRegion>MA</wicri:noRegion>
</affiliation>
</author>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The Gly2019Ser mutation in <italic>LRRK2 </italic>
is not fully penetrant in familial Parkinson's disease: the GenePD study</title>
<author><name sortKey="Latourelle, Jeanne C" sort="Latourelle, Jeanne C" uniqKey="Latourelle J" first="Jeanne C" last="Latourelle">Jeanne C. Latourelle</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA</wicri:regionArea>
<wicri:noRegion>MA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sun, Mei" sort="Sun, Mei" uniqKey="Sun M" first="Mei" last="Sun">Mei Sun</name>
<affiliation wicri:level="1"><nlm:aff id="I2">Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School Boston, MA</wicri:regionArea>
<wicri:noRegion>MA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lew, Mark F" sort="Lew, Mark F" uniqKey="Lew M" first="Mark F" last="Lew">Mark F. Lew</name>
<affiliation wicri:level="4"><nlm:aff id="I3">Department of Neurology, University of Southern California, Los Angeles, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of Southern California, Los Angeles, CA</wicri:regionArea>
<orgName type="university">Université de Californie du Sud</orgName>
<placeName><settlement type="city">Los Angeles</settlement>
<region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Suchowersky, Oksana" sort="Suchowersky, Oksana" uniqKey="Suchowersky O" first="Oksana" last="Suchowersky">Oksana Suchowersky</name>
<affiliation wicri:level="4"><nlm:aff id="I4">Departments of Clinical Neurosciences and Medical Genetics, University of Calgary, Calgary, Alberta, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Departments of Clinical Neurosciences and Medical Genetics, University of Calgary, Calgary, Alberta</wicri:regionArea>
<orgName type="university">Université de Calgary</orgName>
<placeName><settlement type="city">Calgary</settlement>
<region type="state">Alberta</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name>
<affiliation wicri:level="1"><nlm:aff id="I5">Department of Neurology, Medical University of Lübeck, Lübeck, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Medical University of Lübeck, Lübeck</wicri:regionArea>
<wicri:noRegion>Lübeck</wicri:noRegion>
<wicri:noRegion>Lübeck</wicri:noRegion>
<wicri:noRegion>Lübeck</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Golbe, Lawrence I" sort="Golbe, Lawrence I" uniqKey="Golbe L" first="Lawrence I" last="Golbe">Lawrence I. Golbe</name>
<affiliation wicri:level="1"><nlm:aff id="I6">Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ</wicri:regionArea>
<wicri:noRegion>NJ</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mark, Margery H" sort="Mark, Margery H" uniqKey="Mark M" first="Margery H" last="Mark">Margery H. Mark</name>
<affiliation wicri:level="1"><nlm:aff id="I6">Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ</wicri:regionArea>
<wicri:noRegion>NJ</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Growdon, John H" sort="Growdon, John H" uniqKey="Growdon J" first="John H" last="Growdon">John H. Growdon</name>
<affiliation wicri:level="1"><nlm:aff id="I7">Department of Neurology, Massachusetts General Hospital, Harvard Medical School Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Massachusetts General Hospital, Harvard Medical School Boston, MA</wicri:regionArea>
<wicri:noRegion>MA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wooten, G Frederick" sort="Wooten, G Frederick" uniqKey="Wooten G" first="G Frederick" last="Wooten">G Frederick Wooten</name>
<affiliation wicri:level="1"><nlm:aff id="I8">Department of Neurology, University of Virginia Health System, Charlottesville, VA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of Virginia Health System, Charlottesville, VA</wicri:regionArea>
<wicri:noRegion>VA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Watts, Ray L" sort="Watts, Ray L" uniqKey="Watts R" first="Ray L" last="Watts">Ray L. Watts</name>
<affiliation wicri:level="1"><nlm:aff id="I9">Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of Alabama at Birmingham, Birmingham, AL</wicri:regionArea>
<wicri:noRegion>AL</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Guttman, Mark" sort="Guttman, Mark" uniqKey="Guttman M" first="Mark" last="Guttman">Mark Guttman</name>
<affiliation wicri:level="4"><nlm:aff id="I10">Department of Medicine, University of Toronto, Toronto, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Medicine, University of Toronto, Toronto</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Racette, Brad A" sort="Racette, Brad A" uniqKey="Racette B" first="Brad A" last="Racette">Brad A. Racette</name>
<affiliation wicri:level="4"><nlm:aff id="I11">Department of Neurology, Washington University School of Medicine, Saint Louis, MO, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Washington University School of Medicine, Saint Louis, MO</wicri:regionArea>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
<placeName><settlement type="city">Saint-Louis (Missouri)</settlement>
<region type="state">Missouri (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Perlmutter, Joel S" sort="Perlmutter, Joel S" uniqKey="Perlmutter J" first="Joel S" last="Perlmutter">Joel S. Perlmutter</name>
<affiliation wicri:level="4"><nlm:aff id="I11">Department of Neurology, Washington University School of Medicine, Saint Louis, MO, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Washington University School of Medicine, Saint Louis, MO</wicri:regionArea>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
<placeName><settlement type="city">Saint-Louis (Missouri)</settlement>
<region type="state">Missouri (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ahmed, Anwar" sort="Ahmed, Anwar" uniqKey="Ahmed A" first="Anwar" last="Ahmed">Anwar Ahmed</name>
<affiliation wicri:level="1"><nlm:aff id="I12">Barrow Neurological Institute, Phoenix, AZ, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Barrow Neurological Institute, Phoenix, AZ</wicri:regionArea>
<wicri:noRegion>AZ</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shill, Holly A" sort="Shill, Holly A" uniqKey="Shill H" first="Holly A" last="Shill">Holly A. Shill</name>
<affiliation wicri:level="1"><nlm:aff id="I13">Sun Health Research Institute, Sun City, AZ, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Sun Health Research Institute, Sun City, AZ</wicri:regionArea>
<wicri:noRegion>AZ</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Singer, Carlos" sort="Singer, Carlos" uniqKey="Singer C" first="Carlos" last="Singer">Carlos Singer</name>
<affiliation wicri:level="1"><nlm:aff id="I14">Department of Neurology, University of Miami, Miami, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of Miami, Miami, FL</wicri:regionArea>
<wicri:noRegion>FL</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Goldwurm, Stefano" sort="Goldwurm, Stefano" uniqKey="Goldwurm S" first="Stefano" last="Goldwurm">Stefano Goldwurm</name>
<affiliation wicri:level="1"><nlm:aff id="I15">Parkinson Institute, Istituti Clinici di Perfezionamento, Milano, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Parkinson Institute, Istituti Clinici di Perfezionamento, Milano</wicri:regionArea>
<wicri:noRegion>Milano</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pezzoli, Gianni" sort="Pezzoli, Gianni" uniqKey="Pezzoli G" first="Gianni" last="Pezzoli">Gianni Pezzoli</name>
<affiliation wicri:level="1"><nlm:aff id="I15">Parkinson Institute, Istituti Clinici di Perfezionamento, Milano, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Parkinson Institute, Istituti Clinici di Perfezionamento, Milano</wicri:regionArea>
<wicri:noRegion>Milano</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zini, Michela" sort="Zini, Michela" uniqKey="Zini M" first="Michela" last="Zini">Michela Zini</name>
<affiliation wicri:level="1"><nlm:aff id="I15">Parkinson Institute, Istituti Clinici di Perfezionamento, Milano, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Parkinson Institute, Istituti Clinici di Perfezionamento, Milano</wicri:regionArea>
<wicri:noRegion>Milano</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Saint Hilaire, Marie H" sort="Saint Hilaire, Marie H" uniqKey="Saint Hilaire M" first="Marie H" last="Saint-Hilaire">Marie H. Saint-Hilaire</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA</wicri:regionArea>
<wicri:noRegion>MA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hendricks, Audrey E" sort="Hendricks, Audrey E" uniqKey="Hendricks A" first="Audrey E" last="Hendricks">Audrey E. Hendricks</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA</wicri:regionArea>
<wicri:noRegion>MA</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="I16">Department of Biostatistics, Boston University School of Medicine, Boston University, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics, Boston University School of Medicine, Boston University, Boston, MA</wicri:regionArea>
<wicri:noRegion>MA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Williamson, Sally" sort="Williamson, Sally" uniqKey="Williamson S" first="Sally" last="Williamson">Sally Williamson</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA</wicri:regionArea>
<wicri:noRegion>MA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nagle, Michael W" sort="Nagle, Michael W" uniqKey="Nagle M" first="Michael W" last="Nagle">Michael W. Nagle</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA</wicri:regionArea>
<wicri:noRegion>MA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wilk, Jemma B" sort="Wilk, Jemma B" uniqKey="Wilk J" first="Jemma B" last="Wilk">Jemma B. Wilk</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA</wicri:regionArea>
<wicri:noRegion>MA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Massood, Tiffany" sort="Massood, Tiffany" uniqKey="Massood T" first="Tiffany" last="Massood">Tiffany Massood</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA</wicri:regionArea>
<wicri:noRegion>MA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Huskey, Karen W" sort="Huskey, Karen W" uniqKey="Huskey K" first="Karen W" last="Huskey">Karen W. Huskey</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA</wicri:regionArea>
<wicri:noRegion>MA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Laramie, Jason M" sort="Laramie, Jason M" uniqKey="Laramie J" first="Jason M" last="Laramie">Jason M. Laramie</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA</wicri:regionArea>
<wicri:noRegion>MA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Destefano, Anita L" sort="Destefano, Anita L" uniqKey="Destefano A" first="Anita L" last="Destefano">Anita L. Destefano</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA</wicri:regionArea>
<wicri:noRegion>MA</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="I16">Department of Biostatistics, Boston University School of Medicine, Boston University, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics, Boston University School of Medicine, Boston University, Boston, MA</wicri:regionArea>
<wicri:noRegion>MA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Baker, Kenneth B" sort="Baker, Kenneth B" uniqKey="Baker K" first="Kenneth B" last="Baker">Kenneth B. Baker</name>
<affiliation wicri:level="1"><nlm:aff id="I17">Departments of Neurology and Neuroscience, Cleveland Clinic Foundation, Cleveland, OH, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Neurology and Neuroscience, Cleveland Clinic Foundation, Cleveland, OH</wicri:regionArea>
<wicri:noRegion>OH</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Itin, Ilia" sort="Itin, Ilia" uniqKey="Itin I" first="Ilia" last="Itin">Ilia Itin</name>
<affiliation wicri:level="1"><nlm:aff id="I17">Departments of Neurology and Neuroscience, Cleveland Clinic Foundation, Cleveland, OH, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Neurology and Neuroscience, Cleveland Clinic Foundation, Cleveland, OH</wicri:regionArea>
<wicri:noRegion>OH</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Litvan, Irene" sort="Litvan, Irene" uniqKey="Litvan I" first="Irene" last="Litvan">Irene Litvan</name>
<affiliation wicri:level="1"><nlm:aff id="I18">Department of Neurology, University of Louisville School of Medicine, Louisville, KY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of Louisville School of Medicine, Louisville, KY</wicri:regionArea>
<wicri:noRegion>KY</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nicholson, Garth" sort="Nicholson, Garth" uniqKey="Nicholson G" first="Garth" last="Nicholson">Garth Nicholson</name>
<affiliation wicri:level="3"><nlm:aff id="I19">Neurology Department, University of Sydney ANZAC Research Institute, Concord Hospital, Sydney, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Neurology Department, University of Sydney ANZAC Research Institute, Concord Hospital, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Corbett, Alastair" sort="Corbett, Alastair" uniqKey="Corbett A" first="Alastair" last="Corbett">Alastair Corbett</name>
<affiliation wicri:level="3"><nlm:aff id="I19">Neurology Department, University of Sydney ANZAC Research Institute, Concord Hospital, Sydney, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Neurology Department, University of Sydney ANZAC Research Institute, Concord Hospital, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nance, Martha" sort="Nance, Martha" uniqKey="Nance M" first="Martha" last="Nance">Martha Nance</name>
<affiliation wicri:level="1"><nlm:aff id="I20">Struthers Parkinson's Center, Park Nicollet Clinic, Golden Valley, MN, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Struthers Parkinson's Center, Park Nicollet Clinic, Golden Valley, MN</wicri:regionArea>
<wicri:noRegion>MN</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Drasby, Edward" sort="Drasby, Edward" uniqKey="Drasby E" first="Edward" last="Drasby">Edward Drasby</name>
<affiliation wicri:level="1"><nlm:aff id="I21">Port City Neurology, Scarborough, ME, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Port City Neurology, Scarborough, ME</wicri:regionArea>
<wicri:noRegion>ME</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Isaacson, Stuart" sort="Isaacson, Stuart" uniqKey="Isaacson S" first="Stuart" last="Isaacson">Stuart Isaacson</name>
<affiliation wicri:level="1"><nlm:aff id="I22">Parkinson's Disease and Movement Disorder Center of Boca Raton, Boca Raton, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Parkinson's Disease and Movement Disorder Center of Boca Raton, Boca Raton, FL</wicri:regionArea>
<wicri:noRegion>FL</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Burn, David J" sort="Burn, David J" uniqKey="Burn D" first="David J" last="Burn">David J. Burn</name>
<affiliation wicri:level="1"><nlm:aff id="I23">Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne</wicri:regionArea>
<wicri:noRegion>Newcastle upon Tyne</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chinnery, Patrick F" sort="Chinnery, Patrick F" uniqKey="Chinnery P" first="Patrick F" last="Chinnery">Patrick F. Chinnery</name>
<affiliation wicri:level="1"><nlm:aff id="I24">Regional Neurosciences Centre, Newcastle University, Newcastle upon Tyne, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Regional Neurosciences Centre, Newcastle University, Newcastle upon Tyne</wicri:regionArea>
<wicri:noRegion>Newcastle upon Tyne</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P" last="Pramstaller">Peter P. Pramstaller</name>
<affiliation wicri:level="1"><nlm:aff id="I25">Department of Neurology, General Regional Hospital Bolzano, Bolzano, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Neurology, General Regional Hospital Bolzano, Bolzano</wicri:regionArea>
<wicri:noRegion>Bolzano</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Al Hinti, Jomana" sort="Al Hinti, Jomana" uniqKey="Al Hinti J" first="Jomana" last="Al-Hinti">Jomana Al-Hinti</name>
<affiliation wicri:level="1"><nlm:aff id="I26">Department of Neurology, University of Arkansas for Medical Sciences, AR, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of Arkansas for Medical Sciences, AR</wicri:regionArea>
<wicri:noRegion>AR</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Moller, Anette T" sort="Moller, Anette T" uniqKey="Moller A" first="Anette T" last="Moller">Anette T. Moller</name>
<affiliation wicri:level="1"><nlm:aff id="I27">Department of Neurology, Aarhus University Hospital, Aarhus, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Neurology, Aarhus University Hospital, Aarhus</wicri:regionArea>
<wicri:noRegion>Aarhus</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ostergaard, Karen" sort="Ostergaard, Karen" uniqKey="Ostergaard K" first="Karen" last="Ostergaard">Karen Ostergaard</name>
<affiliation wicri:level="1"><nlm:aff id="I27">Department of Neurology, Aarhus University Hospital, Aarhus, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Neurology, Aarhus University Hospital, Aarhus</wicri:regionArea>
<wicri:noRegion>Aarhus</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sherman, Scott J" sort="Sherman, Scott J" uniqKey="Sherman S" first="Scott J" last="Sherman">Scott J. Sherman</name>
<affiliation wicri:level="1"><nlm:aff id="I28">Department of Neurology, University of Arizona, Tucson, AZ, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of Arizona, Tucson, AZ</wicri:regionArea>
<wicri:noRegion>AZ</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Roxburgh, Richard" sort="Roxburgh, Richard" uniqKey="Roxburgh R" first="Richard" last="Roxburgh">Richard Roxburgh</name>
<affiliation wicri:level="1"><nlm:aff id="I29">Department of Neurology, Auckland City Hospital, Auckland, New Zealand</nlm:aff>
<country xml:lang="fr">Nouvelle-Zélande</country>
<wicri:regionArea>Department of Neurology, Auckland City Hospital, Auckland</wicri:regionArea>
<wicri:noRegion>Auckland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Snow, Barry" sort="Snow, Barry" uniqKey="Snow B" first="Barry" last="Snow">Barry Snow</name>
<affiliation wicri:level="1"><nlm:aff id="I29">Department of Neurology, Auckland City Hospital, Auckland, New Zealand</nlm:aff>
<country xml:lang="fr">Nouvelle-Zélande</country>
<wicri:regionArea>Department of Neurology, Auckland City Hospital, Auckland</wicri:regionArea>
<wicri:noRegion>Auckland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Slevin, John T" sort="Slevin, John T" uniqKey="Slevin J" first="John T" last="Slevin">John T. Slevin</name>
<affiliation wicri:level="1"><nlm:aff id="I30">Department of Neurology, University of Kentucky College of Medicine, Lexington, KY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of Kentucky College of Medicine, Lexington, KY</wicri:regionArea>
<wicri:noRegion>KY</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cambi, Franca" sort="Cambi, Franca" uniqKey="Cambi F" first="Franca" last="Cambi">Franca Cambi</name>
<affiliation wicri:level="1"><nlm:aff id="I30">Department of Neurology, University of Kentucky College of Medicine, Lexington, KY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of Kentucky College of Medicine, Lexington, KY</wicri:regionArea>
<wicri:noRegion>KY</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gusella, James F" sort="Gusella, James F" uniqKey="Gusella J" first="James F" last="Gusella">James F. Gusella</name>
<affiliation wicri:level="1"><nlm:aff id="I2">Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School Boston, MA</wicri:regionArea>
<wicri:noRegion>MA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Myers, Richard H" sort="Myers, Richard H" uniqKey="Myers R" first="Richard H" last="Myers">Richard H. Myers</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA</wicri:regionArea>
<wicri:noRegion>MA</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">BMC Medicine</title>
<idno type="eISSN">1741-7015</idno>
<imprint><date when="2008">2008</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>We report age-dependent penetrance estimates for leucine-rich repeat kinase 2 (<italic>LRRK2</italic>
)-related Parkinson's disease (PD) in a large sample of familial PD. The most frequently seen <italic>LRRK2 </italic>
mutation, Gly2019Ser (G2019S), is associated with approximately 5 to 6% of familial PD cases and 1 to 2% of idiopathic cases, making it the most common known genetic cause of PD. Studies of the penetrance of <italic>LRRK2 </italic>
mutations have produced a wide range of estimates, possibly due to differences in study design and recruitment, including in particular differences between samples of familial PD versus sporadic PD.</p>
</sec>
<sec sec-type="methods"><title>Methods</title>
<p>A sample, including 903 affected and 58 unaffected members from 509 families ascertained for having two or more PD-affected members, 126 randomly ascertained PD patients and 197 controls, was screened for five different <italic>LRRK2 </italic>
mutations. Penetrance was estimated in families of <italic>LRRK2 </italic>
carriers with consideration of the inherent bias towards increased penetrance in a familial sample.</p>
</sec>
<sec><title>Results</title>
<p>Thirty-one out of 509 families with multiple cases of PD (6.1%) were found to have 58 <italic>LRRK2 </italic>
mutation carriers (6.4%). Twenty-nine of the 31 families had G2019S mutations while two had R1441C mutations. No mutations were identified among controls or unaffected relatives of PD cases. Nine PD-affected relatives of G2019S carriers did not carry the <italic>LRRK2 </italic>
mutation themselves. At the maximum observed age range of 90 to 94 years, the unbiased estimated penetrance was 67% for G2019S families, compared with a baseline PD risk of 17% seen in the non-<italic>LRRK2</italic>
-related PD families.</p>
</sec>
<sec><title>Conclusion</title>
<p>Lifetime penetrance of <italic>LRRK2 </italic>
estimated in the unascertained relatives of multiplex PD families is greater than that reported in studies of sporadically ascertained <italic>LRRK2 </italic>
cases, suggesting that inherited susceptibility factors may modify the penetrance of <italic>LRRK2 </italic>
mutations. In addition, the presence of nine PD phenocopies in the <italic>LRRK2 </italic>
families suggests that these susceptibility factors may also increase the risk of non-<italic>LRRK2</italic>
-related PD. No differences in penetrance were found between men and women, suggesting that the factors that influence penetrance for <italic>LRRK2 </italic>
carriers are independent of the factors which increase PD prevalence in men.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
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<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Canada</li>
<li>Danemark</li>
<li>Italie</li>
<li>Nouvelle-Zélande</li>
<li>Royaume-Uni</li>
<li>États-Unis</li>
</country>
<region><li>Alberta</li>
<li>Californie</li>
<li>Missouri (État)</li>
<li>Ontario</li>
</region>
<settlement><li>Calgary</li>
<li>Los Angeles</li>
<li>Saint-Louis (Missouri)</li>
<li>Sydney</li>
<li>Toronto</li>
</settlement>
<orgName><li>Université de Calgary</li>
<li>Université de Californie du Sud</li>
<li>Université de Toronto</li>
<li>École de médecine (Université Washington de Saint-Louis)</li>
</orgName>
</list>
<tree><country name="États-Unis"><noRegion><name sortKey="Latourelle, Jeanne C" sort="Latourelle, Jeanne C" uniqKey="Latourelle J" first="Jeanne C" last="Latourelle">Jeanne C. Latourelle</name>
</noRegion>
<name sortKey="Ahmed, Anwar" sort="Ahmed, Anwar" uniqKey="Ahmed A" first="Anwar" last="Ahmed">Anwar Ahmed</name>
<name sortKey="Al Hinti, Jomana" sort="Al Hinti, Jomana" uniqKey="Al Hinti J" first="Jomana" last="Al-Hinti">Jomana Al-Hinti</name>
<name sortKey="Baker, Kenneth B" sort="Baker, Kenneth B" uniqKey="Baker K" first="Kenneth B" last="Baker">Kenneth B. Baker</name>
<name sortKey="Cambi, Franca" sort="Cambi, Franca" uniqKey="Cambi F" first="Franca" last="Cambi">Franca Cambi</name>
<name sortKey="Destefano, Anita L" sort="Destefano, Anita L" uniqKey="Destefano A" first="Anita L" last="Destefano">Anita L. Destefano</name>
<name sortKey="Destefano, Anita L" sort="Destefano, Anita L" uniqKey="Destefano A" first="Anita L" last="Destefano">Anita L. Destefano</name>
<name sortKey="Drasby, Edward" sort="Drasby, Edward" uniqKey="Drasby E" first="Edward" last="Drasby">Edward Drasby</name>
<name sortKey="Golbe, Lawrence I" sort="Golbe, Lawrence I" uniqKey="Golbe L" first="Lawrence I" last="Golbe">Lawrence I. Golbe</name>
<name sortKey="Growdon, John H" sort="Growdon, John H" uniqKey="Growdon J" first="John H" last="Growdon">John H. Growdon</name>
<name sortKey="Gusella, James F" sort="Gusella, James F" uniqKey="Gusella J" first="James F" last="Gusella">James F. Gusella</name>
<name sortKey="Hendricks, Audrey E" sort="Hendricks, Audrey E" uniqKey="Hendricks A" first="Audrey E" last="Hendricks">Audrey E. Hendricks</name>
<name sortKey="Hendricks, Audrey E" sort="Hendricks, Audrey E" uniqKey="Hendricks A" first="Audrey E" last="Hendricks">Audrey E. Hendricks</name>
<name sortKey="Huskey, Karen W" sort="Huskey, Karen W" uniqKey="Huskey K" first="Karen W" last="Huskey">Karen W. Huskey</name>
<name sortKey="Isaacson, Stuart" sort="Isaacson, Stuart" uniqKey="Isaacson S" first="Stuart" last="Isaacson">Stuart Isaacson</name>
<name sortKey="Itin, Ilia" sort="Itin, Ilia" uniqKey="Itin I" first="Ilia" last="Itin">Ilia Itin</name>
<name sortKey="Laramie, Jason M" sort="Laramie, Jason M" uniqKey="Laramie J" first="Jason M" last="Laramie">Jason M. Laramie</name>
<name sortKey="Lew, Mark F" sort="Lew, Mark F" uniqKey="Lew M" first="Mark F" last="Lew">Mark F. Lew</name>
<name sortKey="Litvan, Irene" sort="Litvan, Irene" uniqKey="Litvan I" first="Irene" last="Litvan">Irene Litvan</name>
<name sortKey="Mark, Margery H" sort="Mark, Margery H" uniqKey="Mark M" first="Margery H" last="Mark">Margery H. Mark</name>
<name sortKey="Massood, Tiffany" sort="Massood, Tiffany" uniqKey="Massood T" first="Tiffany" last="Massood">Tiffany Massood</name>
<name sortKey="Myers, Richard H" sort="Myers, Richard H" uniqKey="Myers R" first="Richard H" last="Myers">Richard H. Myers</name>
<name sortKey="Nagle, Michael W" sort="Nagle, Michael W" uniqKey="Nagle M" first="Michael W" last="Nagle">Michael W. Nagle</name>
<name sortKey="Nance, Martha" sort="Nance, Martha" uniqKey="Nance M" first="Martha" last="Nance">Martha Nance</name>
<name sortKey="Perlmutter, Joel S" sort="Perlmutter, Joel S" uniqKey="Perlmutter J" first="Joel S" last="Perlmutter">Joel S. Perlmutter</name>
<name sortKey="Racette, Brad A" sort="Racette, Brad A" uniqKey="Racette B" first="Brad A" last="Racette">Brad A. Racette</name>
<name sortKey="Saint Hilaire, Marie H" sort="Saint Hilaire, Marie H" uniqKey="Saint Hilaire M" first="Marie H" last="Saint-Hilaire">Marie H. Saint-Hilaire</name>
<name sortKey="Sherman, Scott J" sort="Sherman, Scott J" uniqKey="Sherman S" first="Scott J" last="Sherman">Scott J. Sherman</name>
<name sortKey="Shill, Holly A" sort="Shill, Holly A" uniqKey="Shill H" first="Holly A" last="Shill">Holly A. Shill</name>
<name sortKey="Singer, Carlos" sort="Singer, Carlos" uniqKey="Singer C" first="Carlos" last="Singer">Carlos Singer</name>
<name sortKey="Slevin, John T" sort="Slevin, John T" uniqKey="Slevin J" first="John T" last="Slevin">John T. Slevin</name>
<name sortKey="Sun, Mei" sort="Sun, Mei" uniqKey="Sun M" first="Mei" last="Sun">Mei Sun</name>
<name sortKey="Watts, Ray L" sort="Watts, Ray L" uniqKey="Watts R" first="Ray L" last="Watts">Ray L. Watts</name>
<name sortKey="Wilk, Jemma B" sort="Wilk, Jemma B" uniqKey="Wilk J" first="Jemma B" last="Wilk">Jemma B. Wilk</name>
<name sortKey="Williamson, Sally" sort="Williamson, Sally" uniqKey="Williamson S" first="Sally" last="Williamson">Sally Williamson</name>
<name sortKey="Wooten, G Frederick" sort="Wooten, G Frederick" uniqKey="Wooten G" first="G Frederick" last="Wooten">G Frederick Wooten</name>
</country>
<country name="Canada"><region name="Alberta"><name sortKey="Suchowersky, Oksana" sort="Suchowersky, Oksana" uniqKey="Suchowersky O" first="Oksana" last="Suchowersky">Oksana Suchowersky</name>
</region>
<name sortKey="Guttman, Mark" sort="Guttman, Mark" uniqKey="Guttman M" first="Mark" last="Guttman">Mark Guttman</name>
</country>
<country name="Allemagne"><noRegion><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name>
</noRegion>
</country>
<country name="Italie"><noRegion><name sortKey="Goldwurm, Stefano" sort="Goldwurm, Stefano" uniqKey="Goldwurm S" first="Stefano" last="Goldwurm">Stefano Goldwurm</name>
</noRegion>
<name sortKey="Pezzoli, Gianni" sort="Pezzoli, Gianni" uniqKey="Pezzoli G" first="Gianni" last="Pezzoli">Gianni Pezzoli</name>
<name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P" last="Pramstaller">Peter P. Pramstaller</name>
<name sortKey="Zini, Michela" sort="Zini, Michela" uniqKey="Zini M" first="Michela" last="Zini">Michela Zini</name>
</country>
<country name="Australie"><noRegion><name sortKey="Nicholson, Garth" sort="Nicholson, Garth" uniqKey="Nicholson G" first="Garth" last="Nicholson">Garth Nicholson</name>
</noRegion>
<name sortKey="Corbett, Alastair" sort="Corbett, Alastair" uniqKey="Corbett A" first="Alastair" last="Corbett">Alastair Corbett</name>
</country>
<country name="Royaume-Uni"><noRegion><name sortKey="Burn, David J" sort="Burn, David J" uniqKey="Burn D" first="David J" last="Burn">David J. Burn</name>
</noRegion>
<name sortKey="Chinnery, Patrick F" sort="Chinnery, Patrick F" uniqKey="Chinnery P" first="Patrick F" last="Chinnery">Patrick F. Chinnery</name>
</country>
<country name="Danemark"><noRegion><name sortKey="Moller, Anette T" sort="Moller, Anette T" uniqKey="Moller A" first="Anette T" last="Moller">Anette T. Moller</name>
</noRegion>
<name sortKey="Ostergaard, Karen" sort="Ostergaard, Karen" uniqKey="Ostergaard K" first="Karen" last="Ostergaard">Karen Ostergaard</name>
</country>
<country name="Nouvelle-Zélande"><noRegion><name sortKey="Roxburgh, Richard" sort="Roxburgh, Richard" uniqKey="Roxburgh R" first="Richard" last="Roxburgh">Richard Roxburgh</name>
</noRegion>
<name sortKey="Snow, Barry" sort="Snow, Barry" uniqKey="Snow B" first="Barry" last="Snow">Barry Snow</name>
</country>
</tree>
</affiliations>
</record>
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